Publications
2023
10/23 - In vitro potency of xeruborbactam in combination with multiple β-lactam antibiotics in comparison with other β-lactam/β-lactamase inhibitor (BLI) combinations against carbapenem-resistant and extended-spectrum β-lactamase-producing Enterobacterales
Olga Lomovskaya, Mariana Castanheira, Jill Lindley, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski, Dongxu Sun, Maxim Totrov, Jeffery Loutit, Michael Dudley
09/23 - New boronate drugs and evolving NDM-mediated beta-lactam resistance
Olga Lomovskaya, Ruslan Tsivkovski, Maxim Totrov, Dana Dressel, Mariana Castanheira, Michael Dudley
2022
03/22 Intrinsic Antibacterial Activity of Xeruborbactam In Vitro: Assessing Spectrum and Mode of Action
Dongxu Sun, Ruslan Tsivkovski, Joe Pogliano, Hannah Tsunemoto, Kirk Nelson, Debora Rubio-Aparicio, Olga Lomovskayaa
03/22 - A synthetic lipopeptide targeting top-priority multi-drug resistant Gram-negative pathogens
Kade D. Roberts, Yan Zhu, Mohammad A.K. Azad, Mei-Ling Han, Jiping Wang, Lynne Wang, Heidi H. Yu, Andrew S. Horne, Jo-Anne Pinson, David Rudd, Nicolas H. Voelcker, Nitin A. Patil, Jinxin Zhao, Xukai Jiang, Jing Lu, Ke Chen, Olga Lomovskaya, Scott J. Hecker, Philip E. Thompson, Roger L. Nation, Michael N. Dudley, David C. Griffith, Tony Velkov, & Jian Li
03/22 - The Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 Restores the Potency of Multiple Oral Beta-Lactam Antibiotics against Beta-Lactamase-Producing Strains of Resistant Enterobacterales
Olga Lomovskaya, Debora Rubio-Aparicio, Ruslan Tsivkovski, Jeff Loutit, Michael Dudley
09/21 - Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate
Serge H . Boyer, Angela Gonzalez-de-Castro, J.A. Hubertus Dielemans, Laurent Lefort, Zuolin Zhu, Matthias Gnahn, Julia Schörghuber, Stefan Steinhofer, André H. M. de Vries, and Scott J. Hecker
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07/21 - QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics
Olga Lomovskaya, Ruslan Tsivkovski, Dongxu Sun, Raja Reddy, Maxim Totrov, Scott Hecker, David Griffith, Jeffery Loutit, and Michael Dudley
06/21 - In Vitro Activity of the Ultra-Broad-Spectrum Beta-lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa
Olga Lomovskaya, Debora Rubio-Aparicio, Kirk Nelson, Dongxu Sun, Ruslan Tsivkovski, Mariana Castanheira, Jill Lindley, Jeffery Loutit and Michael Dudley.
11/20 - In Vivo Activity of QPX7728, an Ultrabroad-Spectrum Beta- Lactamase Inhibitor, in Combination with Beta-Lactams against Carbapenem-Resistant Klebsiella pneumoniae
Mojgan Sabet, Ziad Tarazi, David C. Griffith
11/20 - In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase
Inhibitor QPX7728 in Combination with Meropenem against
Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii
Kirk Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, Maxim Totrov, Michael Dudley, Olga Lomovskaya
08/20 - In Vitro Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales with Varying Intrinsic and Acquired Resistance Mechanisms
Kirk Nelson, Debora Rubio-Aparicio, Dongxu Sun, Michael Dudley, Olga Lomovskaya
06/20 - Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii
Olga Lomovskaya, Kirk Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, Michael N. Dudley
06/20 - Biochemical Characterization of QPX7728, a New Ultrabroad- Spectrum Beta-Lactamase Inhibitor of Serine and Metallo- Beta-Lactamases
Ruslan Tsivkovski, Maxim Totrov, Olga Lomovskaya
06/20 - Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases
Olga Lomovskaya, Ruslan Tsivkovski, Kirk Nelson, Debora Rubio-Aparicio, Dongxu Sun, Maxim Totrov, Michael N. Dudley
2020 - Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases
Scott J. Hecker, K. Raja Reddy, Olga Lomovskaya, David C. Griffith, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski, Dongxu Sun, Mojgan Sabet, Ziad Tarazi, Jonathan Parkinson, Maxim Totrov, Serge H. Boyer, Tomasz W. Glinka, Orville A. Pemberton, Yu Chen, and Michael N. Dudley